Scientists discover gene that could be link to mental illness

STV
Scientists discover gene that could be link to mental illness

Scientists have revealed that they have discovered a gene which may help explain the causes of mental illness.

An international team of scientists, led by the University of Edinburgh,  found that the gene named ABCA13 is partially inactive in patients with severe psychological conditions such as schizophrenia, bipolar disorder and depression.

Identifying the genes which predispose people to psychiatric illness may lead to new treatments and may "open up a whole new area of biology".

Researchers studied the genes of 2,000 psychiatric patients and compared them with those of 2,000 healthy people.

They found that ABCA13 was faulty more frequently in patients with mental illness than in the control group.

Douglas Blackwood, psychiatric genetics professor at the university, said: "This is an exciting step forward in our understanding of the underlying causes of some common mental illnesses. These risk genes could signpost new directions for treatments."

The team believes the gene may influence the way fat molecules are used in brain cells and the research will now focus on exactly how this occurs.

The discovery could lead to drugs that restore mental health in patients with psychiatric illness.

Dr Ben Pickard, who was part of the Edinburgh team but now works at the University of Strathclyde, said: "This study is the first to identify multiple points of DNA damage within a single gene that are linked with psychiatric illness.

"It strongly suggests that this gene may regulate an important part of brain function that fails in individuals diagnosed with these devastating disorders.

"I think it opens up a whole new area of biology which indicates that these conditions are perhaps related at a fundamental level."

The Edinburgh University research is in collaboration with scientists at universities in Aberdeen, Queensland and North Carolina.

The study took around five years to complete and involved patients from Scotland.

The results are published in the American Journal of Human Genetics.